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. 2013 Feb 22;8(2):e57278. doi: 10.1371/journal.pone.0057278

Figure 6. Effect of i.t. administration of PD98059 on ERK phosphorylation in Vc neurons and nocifensive behavior.

Figure 6

A and B: photomicrographs of pERK-IR cells in Vc following 60 g stimulation of the whisker pad skin in ION-CCI rats with i.t. vehicle (A) or PD98059 (B) administration. C: Mean number of pERK-IR cells in naïve and ION-CCI rats with vehicle or PD98059 administration. D–F: Mean head-withdrawal threshold to mechanical stimulation of the whisker pad skin (D), mean head-withdrawal latency to heat stimulation of the whisker pad skin (E) and mean number of face scratches after acetone application to the whisker pad skin (F) in naïve and ION-CCI rats with vehicle or PD98059 administration. *: p<0.05, **: p<0.01 (vehicle vs. PD98059).