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. 2013 Feb 22;8(2):e56955. doi: 10.1371/journal.pone.0056955

Figure 2. Ggn −/− embryos die prior to implantation.

Figure 2

(A) Targeting strategy used for disruption of the mouse Ggn gene and for screening of the targeted ES clones (B) Southern blotting using 5′ and 3′ external probes. (C) Genotyping of pre-implantation embryos collected from Ggn +/− timed mating. *indicates a Ggn −/− embryo identified at morula stage of development. (D) Ggn is expressed in mouse oocytes and pre-implantation embryos. (E) Ggn is expressed at high levels within the adult testis and at a low level in the ovary and somatic tissues. All adult tissues were obtained from 10 weeks-old C57BL/6J mice. The y axis is truncated from 2–80%.