Table 1. Targeted deletion of the mouse Ggn gene resulted in pre-implantation embryonic lethality.
| Age of progeny | Number analysed | Litter size(Mean±S.D.) | Genotype | ||
| Number of Ggn +/+ | Number of Ggn +/− | Number of Ggn −/− | |||
| 3 week | 175 | 7.9±2.1 | 52 (30%) | 123 (70%) | 0 |
| E11.5–E13.5 | 48 | 9.5±2.0 | 13 (27%) | 35 (73%) | 0 |
| E7.5–E8.5 | 48 | 9.7±1.7 | 14 (29%) | 34 (71%) | 0 |
| E2.5–E3.5 | 45 | not analysed | 10 (22%) | 34 (76%) | 1* (2%) |
| 2-cell IVF embryos | 49 | not analysed | 12 (25%) | 27 (55%) | 10 (20%) |
*
indicates a Ggn −/− embryo identified at morula stage of development.