Table 2. Percent Inhibition of nAChR Activity by a Single Concentration of Compounds 16 and 1a.

	hα3β4 nAChR	hα4β2 nAChR
compound	% inhibitiona,b	% inhibitiona,b
1	58.2 ± 9.2	74.0 ± 14.2
2	82.7 ± 3.3	79.3 ± 6.0
3	82.8 ± 11.5	67.3 ± 28.0
4	53.0 ± 9.5	59.0 ± 7.8
5	14.0 ± 6.6	21.8 ± 6.2
6	19.3 ± 24.4	13.3 ± 24.5
1a	NTc	44.1 ± 22.3
D-tubocurarined	54.0 ± 23.5	61.0 ± 27.9
mecamylamined	88.3 ± 13.3	91.8 ± 5.6
KAB-18d	NAe	39.0 ± 11.7

^aPercent inhibition was determined at 10 μM.

^bValues represent means ± SM, n = 2-5.

^cNT = not tested.

^dKnown nicotinic receptor antagonist.

^eNA = no activity at 10 μM.