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Asymmetric alkynoate synthesis.
 | |||||
|---|---|---|---|---|---|
| Entry | R | n | Yield[a][%] | d.r.[b] | ee[c][%] |
| 1 | H | 1 | 87 | > 20:1 | 50 |
| 2 | H | 2 | 53 | > 20:1 | 60 |
| 3 | O(CH2)2O | 2 | 49 | > 20:1 | 46 |
| 4 | H | 3 | 69 | > 20:1 | 70 |
Isolated yield.
Determined from 1H NMR of the crude reaction mixture.
Determined by chiral HPLC after hydrolysis of the disiloxyketal.
