Fig. 5.

μCT analysis of the proximal tibiae of four-month-old OVX mice treated with BMP6 (10 μg/kg), heparin (0.5 IU/g), BMP6 (10 μg/kg) + heparin (0.5 IU/g) and BMP6 (10 μg/kg) + heparin (1 IU/g). One IU/g heparin with BMP6 significantly decreased the bone volume/tissue volume (BV/TV) (a) and the trabecular number (Tb.N.) (b) and increased the trabecular separation (Tb.Sp.) (c) compared to BMP6-treated mice. μCT images of tibiae from all groups of mice (d). Space encircled by the yellow line indicates the bone marrow cavity without trabeculi. *P < 0.05 vs BMP6