Graph 2.

DEXA analysis of tibiae and femurs of four-month-old mice prior and three weeks after OVX (a), followed by seven weeks of therapy (b, c). Mice were treated with BMP6 (10 μg/kg), heparin (0.5 IU/g), BMP6 (10 μg/kg) + heparin (0.5 IU/g) and BMP6 (10 μg/kg) + heparin (1 IU/g). One IU/g heparin with BMP6 significantly decreased BMD values in both femur (b) and tibiae (c) compared to BMP6 treated mice. Decreased BMD values were also seen in mice treated with a lower dose of heparin (0.5 IU/g) and BMP6 (b). #P < 0.05 vs before OVX, *P < 0.05 vs OVX, **P < 0.05 vs OVX BMP6