Table 2.
Ex vivo and in vivo correction of coagulation parameters after BMP6 treatment
| Group | n | PT (%) | APTT (s) | TT (s) | FBG (mg/dl) | F XI |
|---|---|---|---|---|---|---|
| Ex vivo | ||||||
| Control | 5 | 84.6 | NM | NM | 85 | NM |
| BMP6 1 μg | 5 | 86.3 | 22.23 | 69.95 | 80 | 0.25 |
| Hepzyme | 5 | 80.0 | 21.60 | 78.30 | 80 | 0.21 |
| In vivo | ||||||
| Control | 5 | 87.7 | 89.33 | 93.80 | 70 | <0.025 |
| BMP6 10 μg/kg | 5 | 93.3 | 21.26 | 70.60 | 90 | 0.26 |
NM not measurable, APTT activated partial thromboplastin time, PT Prothrombin time, TT thrombin time, F XI coagulation factor XI, FBG fibrinogen
Values are presented as a mean (n = 5 mice per group)