(A): The population mean of HbA1c over time for each treatment group. The estimates are from the analysis of covariance model adjusting for age, gender, baseline value of HbA1c, and treatment assignment. (B): The population mean of insulin use per kilogram of body weight over time (in 3 month interval) for each treatment group. The estimates are from the analysis of covariance model adjusting for age, gender, baseline value of HbA1c, and treatment assignment.