Table 1.
Candidate Gene Marker List*
| Gene | SNP | Base Change | Minor Allele Frequency† | SNP Location/Type |
|---|---|---|---|---|
| Dentin Sialophosphoprotein (DSPP) | rs2615487 | C-T | T (0.28) | intron |
| Tuftelin 1 (TUFT1) | rs3748609 | A-G | C (0.32) | intron |
| Tuftelin 1 (TUFT1) | rs11204846 | A-G | A (0.43) | intron |
| Tuftelin 1 (TUFT1) | rs3748608 | A-G | G (0.30) | intron |
| Tuftelin 1 (TUFT1) | rs7526319 | C-T | T (0.43) | intron |
| Tuftelin 1 (TUFT1) | rs3828054 | A-G | G (0.12) | missense Gln - Arg |
| Tuftelin 1 (TUFT1) | rs6587597 | A-G | G (0.33) | intron |
| Tuftelin 1 (TUFT1) | rs7554707 | G-T | G (0.31) | intron |
| Tuftelin 1 (TUFT1) | rs2337360 | A-G | A (0.43) | intron |
| Secreted Phosphoprotein 1 (SPP1) | rs10516800 | C-G | C (0.25) | nearest gene spp1 |
| Secreted Phosphoprotein 1 (SPP1) | rs6840362 | C-T | T (0.28) | intron |
| Secreted Phosphoprotein 1 (SPP1) | rs10516799 | C-G | G (0.29) | intron |
| Secreted Phosphoprotein 1 (SPP1) | rs11728697 | C-T | C (0.41) | intron |
| Enamelin (ENAM) | rs12640848 | A-G | A (0.33) | intron |
| Enamelin (ENAM) | rs3796704 | A-G | A (0.04) | missense Arg - Gln |
| Enamelin (ENAM) | rs7671281 | C-T | C (0.04) | missense Ile-Thr |
| Aquaporin 5 (AQP5) | rs923911 | A-C | A (0.13) | intron |
| Aquaporin 5 (AQP5) | rs1996315 | A-G | G (0.41) | between AQP6 and AQP5 |
| Matrix Metallopeptidase 20 (MMP20) | rs1784418 | C-T | T (0.47) | intron |
| Matrix Metallopeptidase 20 (MMP20) | rs2245803 | G-T | T (0.36) | missense Lys-Thr |
| Matrix Metallopeptidase 20 (MMP20) | rs7109663 | C-G | C (0.38) | nearest gene MMP20 |
| Kallikrein-related peptidase 4 (KLK4) | rs2235091 | A-G | C (0.38) | intron |
| Kallikrein-related peptidase 4 (KLK4) | rs198969 | C-G | G (0.49) | intron |
*
: SNP information was retrieved from Hapmap Genome Browser release #28 (http://hapmap.ncbi.nlm.nih.gov/cgi-perl/gbrowse/hapmap28_B36/)
†
: Allele frequencies were estimated on founders only;