Table.
PVN Injection of SHU9119 (0.5mM, 60nL) did not alter the sympathoexcitatory responses evoked by PVN injection of NMDA (5mM, 60nL).
| Time | n | Mean ABP (mmHg) | Heart Rate (bpm) | Lumbar SNA (%) | Renal SNA (%) |
|---|---|---|---|---|---|
| aCSF (60 nL) | |||||
| Baseline Values | 5 | 114±9 | 424±23 | -------- | -------- |
| Δ (Before Treatment) | 14±3 | 35±7 | 117±6 | 124±6 | |
| Δ (10 min post) | 19±3 | 41±8 | 122±9 | 128±4 | |
| SHU9119 (0.5 mM, 60 nL) | |||||
| Baseline Values | 5 | 111±6 | 425±24 | -------- | -------- |
| Δ (Before Treatment) | 14±3 | 59±23 | 118±9 | 131±11 | |
| Δ (10 min post) | 19±2 | 55±17 | 128±8 | 131±10 | |
Values are mean ± SEM. NMDA injections were separated by >30 min. Injection of SHU9119 did not attenuate the sympathoexcitatory response to PVN injection of NMDA.