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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Trends Endocrinol Metab. 2012 Jul 18;23(9):459–466. doi: 10.1016/j.tem.2012.06.006

Figure 2. Control of mitochondrial biogenesis by PGC-1.

Figure 2

Interaction between PGC-1 and specific transcription factors orchestrates major functions of mitochondria including fatty acid β-oxidation, the tricarboxylic acid cycle (TCA), mtDNA replication and oxidative phosphorylation and the electron transport chain (OxPhos/ETC) in addition to biogenesis of this organelle. PPARα interacts with its binding partner, the retinoid X receptor (RXR), to control the expression of many fatty acid β-oxidation enzymes. NRF-1 and NRF-2 contribute to the maintenance of mtDNA and the expression of multiple components of the ETC. ERR members regulate the expression of virtually all functions of the mitochondria including those shown here.