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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Trends Endocrinol Metab. 2012 Jul 18;23(9):459–466. doi: 10.1016/j.tem.2012.06.006

Figure 4. PRC response to growth and metabolic stress.

Figure 4

Under normal growth conditions, PRC acts as an immediate early gene product that is transiently elevated upon the initiation of cell growth. The transient induction of PRC and other immediate early genes is an early event in the program leading to cell proliferation. Under conditions of severe stress, resulting from chemical uncoupling or energy starvation, PRC is induced constitutively in cultured cells as a dysregulated response. This latter response is a departure from its normal expression pattern and leads to the induction of a battery of genes associated with the chronic inflammatory response. The induction of this inflammatory response is thought to be adaptive at the cellular level but may be maladaptive at the organismal level and thus associated with a number of age-related diseases.