Figure 4.
Effect of cromolyn on IgE-independent degranulation of PMCs in vitro. PMCs from female rats (a – d) or mice (e – l) were stimulated with thapsigargin (a and e), ionomycin (b and f), substance P (c and g), compound 48/80 (d and h), PMA with ionomycin (i), endothelin-1 (j), adenosine (k), or mouse SCF (l), with or without cromolyn (added simultaneously). N = 3 – 6 per group from 1 – 2 independent experiments. ## p < 0.01, # p < 0.05, †† p < 0.01, † p < 0.05; N.S. not significantly different versus corresponding values (vehicle or 100 μM cromolyn) for groups not treated with stimuli. ** p < 0.01, * p < 0.05; n.s.: p > 0.05.