. Author manuscript; available in PMC: 2013 Feb 24.

Published in final edited form as: Biopharm Drug Dispos. 2009 Oct;30(7):356–365. doi: 10.1002/bdd.677

Table 1. Kinetic constants obtained from Phase I oxidative and Phase II conjugation reactions, mean ± S.E.

		K_m (μM)	V_max (nmol of product/min/mg protein)
Phase I oxidative metabolism
RLM ^*		14.3 ± 1.2	95.7 ± 9.1
RSiM ^*		28.1 ± 1.6	58.5 ± 2.4
Phase II conjugation
RLM	^†G2	20 ± 1.1	112.2 ± 17.2
	^†G3	8.8 ± 0.8	1736 ± 53.6
RSiM	G2	14.6 ± 3.6	229 ± 26.2
	G3	25.3 ± 2.4	152 ± 16

Rat liver microsomes (RLM); rat small intestinal microsomes (RSiM)

^†

see Figure 1 for the prominent glucuronide peaks G2 and G3.