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. Author manuscript; available in PMC: 2013 Feb 24.
Published in final edited form as: Cancer Prev Res (Phila). 2008 Mar 31;1(3):187–191. doi: 10.1158/1940-6207.CAPR-08-0028

Fig. 3.

Fig. 3

The expression of proinflammatory and phase II detoxifying/antioxidant enzymes in the normal mucosa and tumors of Nrf2 knockout mice compared with WT C57BL/6J mice. A, expressions of COX-2 and 5-LOX were significantly elevated in the tumors of Nrf2 knockout mice when compared with normal tissues of knockout mice and tumors of WT mice. The levels of PGE2 (B) and LTB4 (C) were also higher in the tumors of Nrf2 knockout mice. Columns, mean; bars, SD.

*, significantly different from normal mucosa of mice with same phenotype.

†, significantly different from tumors of mice with different phenotypes.

D, expression of phase II detoxifying/antioxidant enzymes in the normal mucosa and tumors of Nrf2 knockout mice compared with WT C57BL/6J mice.