Figure 1. Dose-depended inhibition effect by LXA4 of IL-1β induced collagen degradation by corneal fibroblasts.

Rabbit fibroblasts were cultured in the absence (closed symbols) or presence (open symbols) of IL-1β (0.1ng/mL) and in the presence of the indicated concentrations of LXA4. After incubation of the cells for 48 hours, the amount of degraded collagen in the culture supernatants was determined. Data are expressed as micrograms of hydroxyproline (HYP) per well and are means±SEM of values from an experiment that was repeated three times with similar results. ^bP<0.001(Dunnett's test) versus the value for cells cultured with IL-1β in the absence of LXA4.