Figure 2. Time-depended inhibition effect of LXA4 on IL-1β induced collagen degradation by corneal fibroblasts.

Cells were cultured in collagen gels for the indicated times in the presence of 60µg/mL plasminogen and in the absence (open symbols) or presence of 0.1ng/mL IL-1β (close symbols), in the absence (circles) or presence (squares) of 10nmol/L LXA4, after which the amount of degraded collagen was determined. Data are mean±SEM of values from three experiments. ^bP< 0.001 (Dunnett test) versus the corresponding value for cells cultured with IL-1β and plasminogen.