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Proportion of patients showing marked clinical worsening (ITT set, LOCF analysis). aModerate to severe AD (MMSE 5 to 19 at baseline), receiving donepezil (10 mg/day). bModerate AD (MMSE 10 to 19 at baseline), receiving donepezil (10 mg/day). *P < 0.01 versus placebo added to donepezil; **P < 0.001 versus placebo added to donepezil. AD, Alzheimer's disease; ITT, intention-to-treat; LOCF, last observation carried forward.
