Table 3.
Subcortical volumes in C9ORF72 mutation and healthy control groups
| C9ORF72 | Control | |||||||
|---|---|---|---|---|---|---|---|---|
| % per year | Atrophy (ml/year) | SD | % per year | Atrophy (ml/year) | SD | P value | ||
| Thalamus | Right | 3.4 | 0.16 | 0.17 | -0.2 | -0.02 | 0.08 | 0.006 |
| Left | 2.5 | 0.23 | 0.29 | -0.3 | -0.02 | 0.09 | 0.03 | |
| Globus pallidus | Right | 1.7 | 0.05 | 0.10 | 0.0 | 0.00 | 0.03 | n/s |
| Left | 2.9 | 0.03 | 0.14 | -1.1 | -0.02 | 0.06 | 0.04 | |
| Caudate | Right | -2.6 | -0.09 | 0.15 | 0.3 | 0.01 | 0.06 | n/s |
| Left | 0.7 | 0.02 | 0.07 | 0.0 | 0.00 | 0.13 | n/s | |
| Amygdala | Right | -2.8 | -0.04 | 0.08 | 0.1 | 0.00 | 0.04 | n/s |
| Left | 2.1 | 0.03 | 0.06 | 0.6 | 0.01 | 0.06 | n/s | |
| Hippocampus | Right | 1.7 | 0.07 | 0.08 | 1.0 | 0.04 | 0.06 | n/s |
| Left | 1.4 | 0.05 | 0.03 | 0.6 | 0.03 | 0.09 | n/s | |
| Putamen | Right | -0.6 | -0.03 | 0.10 | 0.0 | 0.00 | 0.06 | n/s |
| Left | -1.2 | -0.06 | 0.13 | -0.1 | 0.00 | 0.10 | n/s | |
Mean annualised rates of change are expressed as a percentage (%) and as the millilitre (ml) change from baseline. C9ORF72, chromosome 9 open reading frame 72; n/s, not significant p < 0.05; SD, standard deviation.