Table 4.

Stroke odds ratio for E-alone and E+P, by genotype of SNPs in PCSK9 region

		SNP genotype
	Number of cases	AA		AG		GG
		OR	95% CI	OR	95% CI	OR	95% CI	p-2df	p-1df
rs630431
E-alone
All	351	1.704	(1.227, 2.366)	1.064	(0.772, 1.468)	0.871	(0.499, 1.519)	0.04796	0.0166
Ischemic	263	1.994	(1.362, 2.919)	1.321	(0.906, 1.925)	0.767	(0.393, 1.498)	0.03845	0.01104
Hemorrhagic	48	0.651	(0.252, 1.678)	0.682	(0.306, 1.517)	0.682	(0.114, 4.079)	0.9971	0.94614
E+P
All	438	0.935	(0.719, 1.217)	1.616	(1.192, 2.191)	1.978	(1.021, 3.834)	0.00919	0.00291
Ischemic	319	0.916	(0.667, 1.257)	1.550	(1.094, 2.197)	2.434	(1.126, 5.260)	0.01578	0.00401
Hemorrhagic	76	0.724	(0.399, 1.314)	2.143	(0.932, 4.929)	0.953	(0.192, 4.719)	0.10243	0.14652
rs568052
E-alone
All	351	1.716	(1.233, 2.389)	1.050	(0.762, 1.446)	0.909	(0.524, 1.575)	0.04909	0.01939
Ischemic	263	2.019	(1.373, 2.967)	1.294	(0.889, 1.882)	0.818	(0.424, 1.578)	0.04487	0.01272
Hemorrhagic	48	0.651	(0.252, 1.678)	0.682	(0.306, 1.517)	0.682	(0.114, 4.079)	0.9971	0.94614
E+P
All	438	0.961	(0.738, 1.251)	1.555	(1.150, 2.103)	1.978	(1.021, 3.834)	0.02051	0.0061
Ischemic	319	0.953	(0.693, 1.309)	1.474	(1.043, 2.082)	2.434	(1.126, 5.260)	0.03335	0.00918
Hemorrhagic	76	0.724	(0.399, 1.314)	2.143	(0.932, 4.929)	0.953	(0.192, 4.719)	0.10243	0.14652

OR, estimated intervention odds ratio. p-2df, P-value regressing randomization assignment on indicator for one or two minor alleles. p-1df, P-value regressing randomization assignment on number of minor alleles. CI, confidence interval.