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. 2012 Dec 13;4(12):96. doi: 10.1186/gm397

Table 2.

Examples of genetic factors implicated in schizophrenia

Chromosomal location Candidate gene Encoded protein Major function Reference(s)
22q11 COMT Catechol-O-methyltransferase Monoamine metabolism [14-16]
6p22 DTNBP1 Dystrobrevin binding protein 1 Organelle biogenesis [15,16]
8p12 NRG1 Neuregulin 1 Signal transduction in cell-cell interactions [14-18]
1q23.3 RGS4 Regulator of G protein signaling 4 Regulation of G proteins [15,16]
7q21.1 GRM3 Metabotropic glutamate receptor 3 Excitatory glutamatargic neurotransmission [15]
13q34 G72 D-Amino acid oxidase activator Degradation of D-serine, involved in NMDA-type neurotransmission [14,15]
8p21.3 PPP3CC Catalytic subunit of protein phosphatase 3 Regulation of dopaminergic signal transduction [14,16]
15q14 CHRNA7 Nicotinic acetylcholine receptor Cholinergic synaptic transmission [16]
22q11.21 PRODH Proline dehydrogenase (oxidase) 1 Proline degradation [14,16]
6p21.3-22.1 MHC region MHC proteins Crucial parts in immune system [20,21,23]
2q32.1 ZNF804A Zinc finger protein 804A Not fully characterized [19,22]
18q21.2 TCF4 Transcription factor 4 Involved in nervous system development [21,23]
11q24.2 NRGN Neurogranin Postsynaptic protein kinase pathway [23]
1p21.3 MIR137 MicroRNA 137 Not fully characterized [21]
Copy number or structural variants

Chromosomal location Representative genes in the region Reference(s)

1q21.1 CHD1L, GPR89B, BCL9, PRKAB2 and others [24-26]
15q11.2 CYFIP1, TUBGCP5, NIPA1, NIPA2 [24]
15q13.3 CHRNA7, KLF13, OTUD7A, TRPM1 and others [24,26]
16p11.2 KCTD13, MAPK3, TAOK2, CDIPT and others [29]
22q11.2 COMT, PRODH, SLC25A1, CLDN5, TBX1 and others [26,28]

MHC, major histocompatibility complex; NMDA, N-methyl-D-aspartate.

HHS Vulnerability Disclosure