Table 2.
Common SNPs across the IL28B gene region have very different minor allele frequencies in the major ethnic groups
| Location | SNP | OR | %CEU | %CHI | %YRI |
|---|---|---|---|---|---|
| 5' | rs7248668 | 2.24b | 17 | 7 | 6 |
| 5' | rs8099917c | 1.91b | 17 | 8 | 6 |
| 5' | rs8109886 | 0.67a | 43 | 7 | 80 |
| 5', CpG | rs4803221 | 2.24b | 17 | 7 | 18 |
| 5', CpG | rs12979860c | 1.99b | 32 | 8 | 60 |
| Exon 2 | rs8103142 | 1.50b | 27 | 4 | 56 |
| Intron 2 | rs11881222 | 2.02b | 30 | 7 | 31 |
| 3' | rs688187 | 1.94b | 32 | 7 | 59 |
| 3' | rs8105790 | 1.63b | 17 | 7 | 19 |
| 3' | rs12982533 | 2.01b | 31 | 8 | 39 |
| 3' | rs12980275 | 1.79b | 31 | 8 | 51 |
aMinor allele predicts treatment success. bMinor allele predicts treatment failure. cSNPs currently used in genotyping to decide treatment for CHC. %, Percentage of SNPs in major ethnic groups. CEU, European; CHI, Han Chinese; YRI, Yorubi Africans. SNP frequencies are from the 1000 Genome Project pilot genotyping data.