Table 11.
MeSHOP similarity analysis of known breast cancer genes with seven or more observed mutations
| Chromosomal location/gene(s) | Mutations observed | MeSHOP similarity rank |
|---|---|---|
| TP53 | 38 | 1 |
| PIK3CA | 33 | 55 |
| chr17:37833600-38018803/ERBB2 | 21 | 2 |
| GATA3 | 15 | 773 |
| chr8:37353781-37489508/FGFR1/ZNF703 | 15 | 191/8,493 |
| chr8:128504497-128948225/MYC | 15 | 19 |
| chr11:69224506-69556470/CCND1 | 11 | 9 |
| MAP3K1 | 9 | 417 |
| chr20:52065876-52723895/ZNF217 | 9 | 2,102 |
| PTEN | 7 | 12 |
| NCOR1 | 7 | 360 |
| CDKN2A | 7 | 6 |
| CDH1 | 7 | 11 |
Genes known to be implicated in breast cancer from Supplementary Table 4 of [45] are compared to the MeSHOP similarity ranking of human genes for breast neoplasms. The rows in italics highlight genes with a MeSHOP similarity rank less than 13.