Table 1.
Classification: phylum/class/family/genusa | Tanner 1 (mean ± SE) | * | Tanner 5 (mean ± SE) | Adjusted P-value |
Actinobacteria (other) | 2.1 ± 0.7% | ≈ | 0.8 ± 0.4% | 0.154b |
Corynebacteriaceae | 8.8 ± 2.2% | << | 65.0 ± 6.0% | 1.18E-06 |
Propionibacteriaceae | 0.2 ± 0.1% | << | 20.6 ± 4.8% | 0.0027 |
Corynebacterium | 8.7 ± 2.2% | << | 49.6 ± 5.6% | 0.0001 |
Propionibacterium | 0.1 ± 0.1% | << | 20.6 ± 4.8% | 0.0055 |
Rothia | 1.4 ± 0.5% | > | 0.1 ± 0.1% | 0.0249 |
Turicella | 0.0 ± 0.0% | << | 15.4 ± 4.2% | 0.0119 |
Bacteroidetes (other) | 5.1 ± 1.6% | >> | 0.5 ± 0.3% | 0.0158 |
Capnocytophaga | 0.7 ± 0.2% | > | 0.0 ± 0.0% | 0.0007 |
Paraprevotella | 0.7 ± 0.2% | > | 0.0 ± 0.0% | 0.0069 |
Porphyromonas | 1.4 ± 0.5% | > | 0.2 ± 0.2% | 0.041 |
Prevotella | 0.6 ± 0.2% | > | 0.1 ± 0.0% | 0.0201 |
Firmicutes (other) | 10.6 ± 1.9% | >> | 1.9 ± 0.9% | 0.0009 |
Staphylococcaceae | 8.7 ± 3.7% | > | 6.4 ± 2.9% | 0.6836b |
Streptococcaceae | 18.2 ± 3.7% | >> | 0.7 ± 0.5% | 0.0003 |
Clostridia | 2.7 ± 0.8% | ≈ | 2.8 ± 0.7% | 0.9342b |
Dolosigranulum | 8.6 ± 2.2% | >> | 1.7 ± 0.9% | 0.0144 |
Gemella | 1.7 ± 0.6% | > | 0.0 ± 0.0% | 0.0143 |
Granulicatella | 1.2 ± 0.4% | > | 0.0 ± 0.0% | 0.0229 |
Streptococcus | 18.1 ± 3.7% | >> | 0.7 ± 0.5% | 0.0006 |
Fusobacteria | ||||
Fusobacterium | 0.6 ± 0.3% | > | 0.0 ± 0.0% | 0.0403 |
Proteobacteria (other) | 0.1 ± 0.1% | ≈ | 0.0 ± 0.0% | 0.3356b |
Alphaproteobacteria | 0.3 ± 0.1% | > | 0.1 ± 0.0% | 0.0317 |
Betaproteobacteria | 12.2 ± 5.1% | >> | 0.8 ± 0.4% | 0.0365 |
Gammaproteobacteria | 29.6 ± 7.2% | >> | 0.3 ± 0.1% | 0.0009 |
Neisseria | 2.3 ± 0.9% | > | 0.1 ± 0.1% | 0.0201 |
Haemophilus | 3.7 ± 1.5% | > | 0.0 ± 0.0% | 0.0256 |
Moraxella | 24.1 ± 7.0% | >> | 0.0 ± 0.0% | 0.0055 |
aRepresents proportion in the microbiome as a whole, not a subset of the taxonomy. Higher taxonomic levels are listed first. bNot significant; see Additional file 2 for additional details. *Greater or less than; double signs indicate a difference of notable magnitude.