Table 1.
Characteristics of subjects
| Characteristic | AD (n = 78) |
aMCI (n = 59) |
Normal Control (n = 66) |
P* |
|---|---|---|---|---|
| Demographic | ||||
| Age, y (mean, SD) | 75.7 (8.4) | 71.3 (8.5) | 71.1 (8.3) | 0.0005 |
| Female, N (%) | 47 (60%) | 28 (43%) | 24 (36%) | 0.017 |
| Education, y (mean, SD) | 11.4 (2.8) | 12.8 (3.5) | 13.1 (2.7) | 0.0005 |
| Clinical | ||||
| Statin Use, N (%) | 16 (21%) | 17 (28.8%) | 11 (17%) | 0.26 |
| BMI (mean, SD) | 25.4 (3.2) | 25.6 (3.9) | 24.6 (3.7) | 0.33 |
| ESC score (mean, SD) | 0.133 (0.110) | 0.094 (0.102) | 0.103 (0.078) | 0.015 |
| Diabetes type 1 or 2, N (%) | 6 (7.7%) | 1 (1.7%) | 3 (4.5%) | 0.30 |
| History of heart disease, N (%) | 8 (10.3%) | 9 (15.3%) | 7 (10.6%) | 0.68 |
| Hachinski score (mean, SD) | 2.6 (1.9) | 2.5 (2.6) | 0.7 (1.0) | < 0.0001 |
| Scheltens score (mean, SD) | 12.2 (9.9) | 10.8 (10.8) | 6.4 (5.7) | 0.0021 |
| Wahlund score (mean, SD) | 4.0 (2.7) | 3.7 (2.8) | 2.8 (1.7) | 0.04 |
| Duration of symptoms, y (mean, sd) | 2.5 (2.4) | 3.1 (3.3) | NA | 0.63 |
| MMSE, mean (mean, SD) | 23.8 (2.7) | 28 (1.7) | 29.1 (1.0) | < 0.0001 |
| Laboratory | ||||
| LpPLA2, nmol/min/ml (mean, SD) | 197.1 (38.4) | 205.5 (43.4) | 195.4 (41.9) | 0.34 |
| LDL, mmol/L (mean, SD) | 2.9 (1.0) | 2.9 (0.8) | 3.0 (1.2) | 0.79 |
| HDL, mmol/L (mean, SD) | 2.0 (0.5) | 1.8 (0.5) | 1.7 (0.5) | 0.005 |
| Total cholesterol:HDL ratio | 3.0 (0.9) | 3.2 (0.9) | 3.5 (1.2) | 0.012 |
| Homocysteine, Umol/L (mean, sd) | 15.1 (5.4) | 14.1 (7.9) | 12.3 (3.4) | 0.002 |
| HbA1c, % (SD) | 5.6 (0.4) | 5.6 (0.4) | 5.5 (0.3) | 0.43 |
| CSF markers of AD | ||||
| Aβ42, pg/ml (mean, SD) | 421.4 (147.6) | 568.2 (251.7) | 809.7 (260.5) | < 0.0001 |
| CSF T-Tau, pg/ml (mean, SD) | 698.5 (317.2) | 417.2 (245.6) | 308.0 (195.9) | < 0.0001 |
| CSF P-Tau, pg/ml (mean, SD) | 101.9 (58.0) | 62.9 (27.9) | 52.0 (21.6) | < 0.0001 |
| Genetic | ||||
| APOE ε4-positive, N (%) | 45 (58%) | 30 (50.5%) | 4 (6%) | NA† |
*ANOVA for normally distributed continuous variables, Kruskal-Wallis test for non-normal continuous variables, Fisher's exact test for ordinal variables. † Control selection was not independent of APOE status.