Table 1.
Patient demographics and clinical data
| Synovia | Nodules | |||
|---|---|---|---|---|
| Smokers(n = 6*) | Non-smokers(n = 11*) | Smokers(n = 4) | Non-smokers(n = 14) | |
| Female, % | 83 | 64 | 100 | 71 |
| Age, years** | 58 (37-79) | 55 (35-74) | 47 (44-50) | 61(48-77) |
| Disease duration, years** | 11 (2-30) | 18 (3-30) | 19 (13-30) | 19 (2-44) |
| Nodules, n | 5 (83%) | 9 (82%) | 4 (100%) | 14 (100%) |
| Erosions, n | 6 (100%) | 10 (91%) | 4 (100%) | 13 (93%) |
| RF positive, n | 6 (100%) | 10 (91%) | 4 (100%) | 13 (93%) |
| ACPA Positive†, n/total ACPA Titer†† | 5/5 (100%) 157 ± 45 |
8/9 (89%) 177 ± 26 |
4/4 (100%) 193 ± 57 |
12/13 (92%) 157 ± 22 |
| ESR** | 34 (3-85) | 33 (13-64) | 30 (13-64) | 33 (6-54) |
* Three patients (one smoker, two non-smokers) provided two synovial samples. ** mean values with the range in parenthesis. †For some patients, tissue samples pre-dated the availability of tests for anticitrullinated peptide antibody (ACPA); †† Mean values ± SEM. Mean ACPA titers were not significantly different. n, number of patients; RF, rheumatoid factor; SEM, standard error of the mean,]; ESR, erythrocyte sedimentation rate.