Table 2.
AS baseline parameters considered as predictors of anti-TNF response and persistent inflammation (CRP ≥ 5 mg/L) at 12 months
| Baseline parameters | CRP ≥ 5 mg/L n = 10 |
CRP < 5 mg/L n = 20 |
P |
|---|---|---|---|
| Age, years | 31.6 ± 10.8 | 37.7 ± 10.8 | 0.157 |
| Disease duration, years | 10.6 ± 8.9 | 12.5 ± 9.4 | 0.598 |
| mSASSS | 16.5 ± 14.9 | 23.35 ± 19.0 | 0.329 |
| BMD lumbar spine, g/cm2 | 1.020 ± 0.191 | 1.040 ± 0.168 | 0.771 |
| BASDAI | 4.89 ± 2.1 | 5.56 ± 2.2 | 0.415 |
| C-reactive protein, mg/L | 58.13 ± 71.1 | 26.5 ± 27.4 | 0.166 |
| ESR, mm/hr | 38.5 ± 34.9 | 16.7 ± 9.8 | 0.176 |
| MMP-3, ng/mL | 70.2 ± 52.3 | 37.8 ± 33.0 | 0.090 |
| Sclerostin, pmol/L | 41.4 ± 19.5 | 70.0 ± 33.3 | 0.023 |
Values are expressed as mean (SD). AS, ankylosing spondylitis; mSASSS, modified Stoke Ankylosing Spondylitis Spine Score; BMD, bone mineral density; BASDAI, Bath AS Disease Activity Index; ESR, erythrocyte sedimentation rate; MMP-3, matrix metalloproteinase 3.