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LS mean pain VAS score. Weekly assessment analyses based on the results of the MMRM analysis with weekly mean VAS score. Scores range from 0 to 100 with higher scores indicating increased pain. Mean value (± SE) shown for each time point, where *P ≤0.025, **P ≤0.001 and ***P ≤0.0001 for each treatment time point compared with placebo.
