Table 2.
Microarray gene expression of soleus muscle-fiber energy metabolism and gene products involved in fiber-type regulation
| Gene description (gene symbol) | FC | P value | q value |
|---|---|---|---|
| Respiratory chain complex I | |||
| NADH dehydrogenase (ubiquinone) 1α subcomplex, 4 (Ndufa4) | -1.1 | 0.007 | 0.999 |
| NADH dehydrogenase (ubiquinone) 1α/β subcomplex, 1 (Ndufab1) | 1.0 | 0.507 | 0.999 |
| NADH dehydrogenase (ubiquinone) 1α subcomplex, assembly factor 1 (Ndufaf1) | -1.1 | 0.110 | 0.999 |
| NADH dehydrogenase (ubiquinone) 1β subcomplex 3 (Ndufb3) | -1.0 | 0.772 | 0.999 |
| NADH dehydrogenase (ubiquinone) 1β subcomplex, 5 (Ndufb5) | -1.1 | 0.036 | 0.999 |
| NADH dehydrogenase (ubiquinone) 1 β subcomplex, 9 (Ndufb9) | -1.0 | 0.286 | 0.999 |
| NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1 (Ndufc1) | -1.1 | 0.167 | 0.999 |
| NADH dehydrogenase (ubiquinone) Fe-S protein 1 (Ndufs1) | -1.1 | 0.045 | 0.999 |
| NADH dehydrogenase subunit 1 (mt-ND1) | -1.1 | 0.267 | 0.999 |
| NADH dehydrogenase subunit 2 (mt-ND2) | -1.1 | 0.087 | 0.999 |
| NADH dehydrogenase subunit 4L (mt-ND4l) | -1.1 | 0.004 | 0.999 |
| NADH dehydrogenase subunit 5 (mt-ND5) | -1.1 | 0.002 | 0.999 |
| NADH dehydrogenase subunit 6 (mt-ND6) | -1.2 | 0.364 | 0.999 |
| Respiratory chain complex II | |||
| Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb) | -1.4 | 0.00001 | 0.139 |
| Respiratory chain complex III | |||
| Ubiquinol-cytochrome c reductase binding protein (Uqcrb) | -1.1 | 0.003 | 0.999 |
| Ubiquinol-cytochrome c reductase core protein I (Uqcrc1) | -1.0 | 0.677 | 0.999 |
| Ubiquinol cytochrome c reductase core protein 2 (Uqcrc2) | -1.1 | 0.039 | 0.999 |
| Respiratory chain complex IV | |||
| Cytochrome c oxidase, subunit Va (Cox5a) | -1.1 | 0.205 | 0.999 |
| Cytochrome c oxidase subunit Vb (Cox5b) | -1.0 | 0.442 | 0.999 |
| Cytochrome c oxidase, subunit VIa, polypeptide 2 (Cox6a2) | -1.1 | 0.096 | 0.999 |
| Cytochrome c oxidase, subunit VIc (Cox6c) | -1.1 | 0.144 | 0.999 |
| Cytochrome c oxidase subunit VIIb (Cox7b) | 1.0 | 0.501 | 0.999 |
| Cytochrome c oxidase, subunit VIIa 2 (Cox7a2) | -1.1 | 0.006 | 0.999 |
| Cytochrome c oxidase subunit VIIa polypeptide 2 like (Cox7a2l) | -1.2 | 0.002 | 0.999 |
| Cytochrome c oxidase subunit I (mt-Co1) | -1.1 | 0.000 | 0.999 |
| Cytochrome c oxidase subunit II (mt-Co2) | -1.1 | 0.028 | 0.999 |
| Respiratory chain complex V | |||
| ATP synthase, F1 complex, γ polypeptide 1 (Atp5c1) | 1.0 | 0.807 | 0.999 |
| ATP synthase, F0 complex, subunit C3 (subunit 9) (Atp5g3) | -1.1 | 0.080 | 0.999 |
| ATP synthase GA binding protein transcription factor, α subunit: (Gabpa: Atp5j) | -1.2 | 0.005 | 0.999 |
| ATP synthase, F0 complex, subunit F2 (Atp5j2) | 1.0 | 0.548 | 0.999 |
| ATP synthase F0 subunit 6 (mt-atp6) | -1.3 | 0.739 | 0.999 |
| ATP synthase F0 subunit 8 (mt-atp8) | -1.1 | 0.016 | 0.999 |
| Glycolysis | |||
| Phosphofructokinase, muscle (Pfkm) | 2.1 | 1.00E-35 | 1.00E-35 |
| Pyruvate kinase, muscle (Pkm2) | 2.7 | 1.00E-35 | 1.00E-35 |
| 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3) | 2.9 | 1.19E-13 | 3.26E-09 |
| Glycogenolysis | |||
| Phosphorylase, glycogen, muscle (Pygm) | 1.3 | 1.78E-14 | 4.88E-10 |
| Phosphoglucomutase 1 (Pgm1) | 2.8 | 1.00E-35 | 1.00E-35 |
| Phosphoglucomutase 2-like 1 (Pgm2l1) | 2.2 | 1.19E-13 | 3.25E-09 |
| Fatty acid ß-oxidation | |||
| Carnitine palmitoyltransferase 1b, muscle (CPT1b) | -1.4 | 3.52E-07 | 0.009 |
| Hydroxyacyl-Coenzyme A dehydrogenase (Hadh) | -1.6 | 2.02E-07 | 0.005 |
| Regulator genes (muscle fiber-type switch) | |||
| SRY (sex-determining region Y)-box 6 (Sox6) | 5.2 | 1.00E-35 | 1.00E-35 |
| Myogenic differentiation 1 (Myod1) | 4.4 | 1.11E-16 | 3.06E-12 |
| Myogenin (Myog) | -3.7 | 1.78E-09 | 4.82E-05 |
| Regulator of calcineurin 1 (Rcan1) | -4.6 | 3.51E-13 | 9.61E-09 |
| SIX homeobox 1 (Six1) | 2.0 | 5.68E-12 | 1.55E-07 |
| SIX homeobox 2 (Six2) | 5.0 | 9.39E-13 | 2.57E-08 |
| Myostatin (Mstn) | 4.4 | 3.74E-13 | 1.03E-08 |
| Estrogen-related receptor γ (Esrrg) | -2.1 | 1.07E-10 | 2.91E-06 |
| NFAT activating protein with ITAM motif 1 (Nfam1) | -1.7 | 3.34E-08 | 8.96E-04 |
The fold-change (FC) value indicates the relative amounts of transcripts in rats treated with zidovudine, compared with control animals. The Benjamini Hochberg q value indicates the false-discovery rate.