Table 4.

Correlation of changes in IGF-1, pain, and pain threshold, and changes in cerebrospinal markers

	ΔIGF-1 (serum)	ΔPain threshold	ΔPain
	0.495	0.539	0.075
ΔCSF SP	P = 0.072	P = 0.038	P = 0.790
	n = 14	n = 15	n = 15
	-0.164	0.335	0.016
ΔCSF NGF	P = 0.558	P = 0.204	P = 0.953
	n = 15	n = 16	n = 16
	0.802	0.288	0.315
ΔCSF NPY	P = 0.001	P = 0.318	P = 0.273
	n = 13	n = 14	n = 14
	-0.165	0.225	-0.119
ΔCSF IL-6	P = 0.573	P = 0.420	P = 0.673
	n = 15	n = 15	n = 15
	-0.164	-0.109	0.103
ΔCSF IL-8	P = 0.558	P = 0.688	P = 0.704
	n = 15	n = 16	n = 16
	-0.156	-0.579	0.329
ΔCSF MMP3	P = 0.594	P = 0.024	P = 0.231
	n = 14	n = 15	n = 15

Median and range (min-max) indicated. Spearmans rho(r^s), two-tailed significance (P), and number of subjects (n) are presented.