Table 3.
Effect of anti-NRP1B treatment on joint inflammation and destruction in mice with collagen-induced arthritis
| Joint findings, % | |||||
|---|---|---|---|---|---|
| Treatment | Normal | Mild | Moderate | Severe | P† |
| PBS | 20.7 | 5.2 | 32.7 | 41.4 | |
| anti-NRP1B | 42.1 | 17.5 | 22.9 | 17.5 | 0.0021 |
Values are the percentage of joints with normal appearance or exhibiting inflammation and cartilage/bone degradation graded as mild, moderate, or severe, as assessed by haematoxylin and eosin. The numbers of joints assessed were as follows: 57 in the phage-derived monoclonal antibody against neuropilin-1 (anti-NRP1B)-treated group and 58 in the PBS-treated group.
† The absolute numbers of mice exhibiting normal, mild, moderate, and severe arthritis changes were compared, and significance versus untreated mice was analysed by chi-square test for trend.