Table 2.
Fractional clearance of urate (%) in healthy subjects in the morning and afternoon on three separate study days
| Subject | Day 1 am | Day 2 am | Day 3 am | Day 1 pm | Day 2 pm | Day 3 pm | Mean |
|---|---|---|---|---|---|---|---|
| V01 | 7.8 | 8.1 | 8.5 | 6.8 | 6.6 | 7.7 | 7.6 |
| V02 | 6.1 | 8.8 | 6.9 | 8.8 | 11.4 | 9.7 | 8.6 |
| V03 | 9.7 | 8.1 | 4.8 | 8.5 | 10.4 | 7.6 | 8.2 |
| V04 | 4.2 | 4.9 | 4.8 | 3.4 | 3.8 | 4.9 | 4.4 |
| V05 | 10.6 | 7.5 | 8.1 | 10.0 | 9.9 | 16.5 | 10.5 |
| V06 | 8.8 | 7.6 | 6.7 | 7.8 | 7.9 | 7.6 | 7.7 |
| V07 | 7.3 | 8.1 | 11.0 | 8.5 | 9.0 | 10.6 | 9.1 |
| V08 | 5.7 | 5.0 | 6.3 | 6.7 | 5.5 | 8.0 | 6.2 |
| V09 | 5.9 | 4.3 | 4.2 | 6.1 | 4.2 | 6.7 | 5.2 |
| V10 | 6.4 | 6.3 | 7.6 | 9.5 | 9.8 | 9.7 | 8.2 |
| V11 | 8.9 | 9.0 | 9.8 | 10.2 | 8.9 | 10.0 | 9.5 |
| V12 | 6.7 | 6.5 | 9.9 | 7.9 | 7.9 | 8.9 | 8.0 |
| V13 | 8.7 | 7.8 | 6.7 | 4.8 | 8.3 | 7.0 | 7.2 |
| Mean | 7.4 | 7.1 | 7.3 | 7.6 | 8.0 | 8.9 | 7.7 |
| 95% CI | 6.3 to 8.5 | 6.2 to 8.0 | 6.1 to 8.6 | 6.4 to 8.8 | 6.5 to 9.4 | 7.1 to 10.5 | 6.7 to 8.7 |
Study 1B; n = 13. Mean age (range) was 35.1 (21 to 73) years.