Table 1.
Binding analysis of 2H- and ILZ-based stradomers to individual FcRs
| FcγRI | FcγRIIb | FcγRIII | FcγRIV | SIGN-R1 | |
|---|---|---|---|---|---|
| IgG2a Fc | 17.4 (4.07) | 289 (1.48) | 248 (2.9) | 27.8 (25.4) | n.s.a |
| 2A-ILZN | 6.71 (52.9) | 3.8 (51.3) | 2.3 (85.4) | .46 (88.3) | 134 (0.43) |
| 2A-ILZC | 63.4 (7.62) | 455 (11) | 151 (16.1) | 63.6 (20) | 43.9 (0.77) |
| 2A-2HN | 16.3 (7.62) | 3.4 (12.1) | 4.4 (24.9) | 7.6 (11.3) | 109 (0.11) |
| 2A-2HC | 9.12 (9.97) | 3.3 (29.2) | 4.2 (40.6) | 3.03 (18.9) | n.s.a |
KD (left, in nM), and χ2 (right, in parenthesis). aInsufficient binding to calculate KD.