Table 1.

Differential diagnosis of idiopathic CD4 lymphocytopenia

Infections	HIV1,2
	HTLV1, 2
	Mycobacterial infections
	EBV, CMV
Malignancies/hematologic conditions	Lymphoma
	Aplastic anemia
	Myelodysplastic syndrome
Autoimmune	Systemic lupus erythematosus
	Sjögren's syndrome
	Kikuchi disease
Medications	Chemotherapy and immunosuppressants
	Corticosteroids
Genetic syndromes	XMEN
	WHIM
	Unc119 mutation
Various	Sarcoidosis
	Common variable immunodeficiency

CMV, cytomegalovirus; EBV, Epstein-Barr virus; Unc119, Uncoordinated 119; WHIM, warts, hypogammaglobulinemia, infections, and myelokathexis; XMEN, X-linked magnesium deficiency with Epstein-Barr virus and neoplasia.