Table 5.
Mean urinary biomarkers of acute kidney injury as a ratio to urinary creatinine.
| Mean (SD) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Treatment group | Baseline | Until HDSa | Day 1 | Day 2 | Day 3 | Day 4 | Day 8b | Lastc |
| Alpha-1-microglobulin/urinary creatinine, g/mmol | ||||||||
| HES 130/0.4 | 17.8 (21.0) | 18.1 (14.8) | 18.3 (16.0) | 19.4 (20.3) | 19.6 (20.5) | 17.2 (14.4) | 13.4 (14.9) | 19.9 (22.7) |
| NaCI 0.9% | 12.3 (12.9) | 17.2 (18.0) | 17.8 (17.1) | 16.9 (15.0) | 16.7 (14.9) | 16.7 (13.8) | 19.5 (23.9) | 19.8 (23.3) |
| Beta-NAG/urinary creatinine, UI/mmol | ||||||||
| HES 130/0.4 | 4.9 (6.6) | 4.1 (3.5) | 5.0 (3.8) | 7.9 (12.8) | 8.1 (13.6) | 5.5 (4.6) | 4.5 (3.0) | 6.7 (10.0) |
| NaCI 0.9% | 4.1 (4.7) | 4.2 (3.5) | 6.0 (9.1) | 4.7 (4.2) | 4.5 (4.4) | 4.2 (3.3) | 5.8 (5.0) | 5.7 (5.5) |
| NGAL/urinary creatinine, μg/mmol | ||||||||
| HES 130/0.4 | 283.0 (785.1) | 352.8 (710.7) | 229.9 (465.5) | 325.9 (1,079.0) | 432.9 (1458.2) | 90.9 (203.4) | 24.4 (71.5) | 279.0 (884.8) |
| NaCI 0.9% | 305.5 (833.9) | 244.9 (452.4) | 318.7 (644.8) | 149.8 (303.2) | 121.1 (306.1) | 112.1 (373.7) | 177.8 (551.5) | 212.8 (604.8) |
aFirst measurement until HDS visit (i.e., data recorded at day of withdrawal were assigned to the study visit corresponding to the actual time point of measurement); bdata recorded on Day 8; clast available post-baseline measurement; HES, hydroxyethyl starch; NaCI, sodium chloride; NAG, N-acetyl-β-D-glucosaminidase; NGAL, neutrophil gelatinase associated lipocalin; SD, standard deviation; HDS, hemodynamic stabilization.