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Effect of the -429T/C polymorphism on the transcription activity of the RAGE promoter. Relative luciferase activity (RLA) was measured in U937 cells transfected with -429T or -429C plasmid constructs as described in methods. The fold increase of RLA was significantly lower in cells transfected with variant C allele than those transfected with wild T allele (P = 0.032).
