Table I.

Effects of fenbendazole on the growth of EMT6 tumors in BALB/c mice. Tumors in these three experiments were injected i.d.; tumor volume was measured three times per week from the time each tumor became palpable until it reached a volume of 1000 mm³. When tumors reached a mean volume of ~100 mm³, mice were stratified by tumor volume into groups and treated. The time needed for each tumor to grow from its volume at stratification to four-times that volume was calculated. Fenbendazole, whether given in the diet or as three daily i.p. injections, did not alter tumor growth in either unirradiated or irradiated tumors. In addition, fenbendazole did not alter the health of the animals and did not alter the number of spontaneous lung metastases seen on necropsy in any of these experiments.

Treatment	Days to four-fold volume (mean±SD)
	Control	Fenbendazole	10 Gy	Fenbendazole + 10 Gy
Fenbendazole given as three daily injections, 50 mg/kg/day, i.p.	10.4±3.0	12.4±2.6	18.3±5.1	17.5±7.5
Growth curves shown in Figure 3
Fenbendazole given as three daily injections 50 mg/kg/day, i.p.	11.4±3.0	11.5±1.0	ND	ND
Growth curves not shown
Fenbendazole in diet, 150 ppm, continually during tumor growth	12.7±0.1	12.1±1.2	17.5±3.7	20.4±2.4
Growth curves published in ref. 10