Table 1.
The Susceptibility Genetic Loci for Type 2 Diabetes [by May-2012]. The References Listed Here Are Those That Firstly Reported the Significant Loci with P Value Less than 5 x 10-8 for the GWAS
| Year | Genes | Location | SNP | Type of SNP | Odds Ratio, 95% Confidence Interval | P-values | References | |
|---|---|---|---|---|---|---|---|---|
| 1 | 2000 | CAPN10 | 2q37.3 | 9803A/G | Missense | - | - | [8] Horikawa Y, Nat Genet 2000 |
| 2 | PPARG | 3p25.2 | rs1801282-C | Missense | 1.25 [Not Reported] | 0.002 | [18] Altshuler D, Nat Genet 2000 | |
| 3 | 2003 | KCNJ11 | 11p15.1 | rs5219-T | Missense | 1. 23 [1.12–1.36] 1.14 [1.10-1.19] |
1.5x10-5 7x10-11 |
[19] Gloyn AL, Diabetes 2003 [28] Scott LJ, Science 2007 |
| rs5215-C | Missense | 1.14 [1.10-1.19] | 5.0x10-11 | [22] Zeggini E, Science 2007 | ||||
| 4 | 2006 | TCF7L2 | 10q25.3 | rs7903146-T | Intron | 1.54 [Not Reported] 1.65 [1.28-2.02] 1.38 [Not Reported] |
2.1x10-9 2.0x10-34 2x10-10 |
[12] Grant SF, Nat Genet. 2006; [24] Sladek R, Nature 2007 [29] Steinthorsdottir V, Nat Genet 2007 |
| 10q25.2 | rs7901695-C | Intron | 1.37 [1.31-1.43] | 1.0x10-48 | [22] Zeggini E, Science 2007 | |||
| 10q25.2 | rs4506565-T | Intron | 1.36 [1.20-1.54] | 5x10-12 | [23] WTCCC, Nature 2007 | |||
| 5 | 2007 | SLC30A8 | 8q24.11 | rs13266634-C | cds-synon | 1.18 [0.69-1.67] 1.12 [1.07-1.16] |
6x10-8 5x10-8 |
[24] Sladek R, Nature 2007 [22] Zeggini E, Science 2007 |
| 6 | WFS1 | 4p16.1 | rs10010131-T | Intron | 0.90 [0.86-0.93] | 1.4x10-7 | [25] Sandhu MS, Nat Genet. 2007 | |
| rs6446482-C | intron | 0.90 [0.87-0.94] | 3.4x10-7 | [25] Sandhu MS, Nat Genet 2007 | ||||
| rs1801214-T | cds-synon | 1.13 [1.08-1.18] | 3x10-8 | [34] Voight BF, Nat Genet 2010 | ||||
| 7 | TCF2 (HNF1B) | 17q12 | rs7501939-C | intron | 0.91 [0.87–0.94] | 9.2x10-7 | [26] Gudmundsson J, Nat Genet 2007 | |
| 17q12 | rs4430796-A | intron | 0.91 [0.87–0.94] | 2.7x10-7 | [26] Gudmundsson J, Nat Genet 2007 | |||
| 8 | HHEX | 10q23.33 | rs1111875-C | intergenic | 1.13 [1.08-1.17] | 6x10-10 | [28] Scott LJ, Science 2007 | |
| rs5015480-C | Intergenic | 1.18 [1.13-1.23] | 1x10-15 | [34] Voight BF, Nat Genet 2010 | ||||
| 9 | IGF2BP2 | 3q27.2 | rs4402960-T | Intron | 1.14 [1.11-1.18] | 9x10-16 | [22] Zeggini E, Science 2007 | |
| rs6769511-C | Intron | 1.23 [1.15-1.31] | 1x10-9 | [27] Unoki H, Nat Genet 2008 | ||||
| 10 | FTO | 16q12.2 | rs8050136-A | Intron | 1.23 [1.18-1.32] | 9x10-16 | [22] Zeggini E, Science 2007 | |
| rs9939609-A | Intron | 1.34 [1.17-1.52] | 2x10-7 | [23] WTCCC, Nature 2007 | ||||
| 11 | CDKAL1 | 6p22.3 | rs10946398-C | Intron | 1.16 [1.10-1.22] | 1x10-8 | [22] Zeggini E, Science 2007 | |
| rs7754840-C | Intron | 1.12 [1.08-1.16] | 4x10-11 | [28] Scott LJ, Science 2007 | ||||
| rs7756992-G | Intron | 1.2 [1.13-1.27] | 8x10-9 | [29] Steinthorsdottir V, Nat Genet 2007 | ||||
| rs9465871-C | Intron | 1.18 [1.04-1.34] | 3x10-7 | [23] WTCCC, Nature 2007 | ||||
| rs4712524-G | intron | 1.22 [1.15-1.31] | 3x10-10 | [27] Unoki H, Nat Genet 2008 | ||||
| 12 | CDKN2A, CDKN2B | 9p21.3 | Rs564398-T | Intron | 1.13 [1.08-1.19] | 1x10-8 | [22] Zeggini E, Science 2007 | |
| rs10811661-T | Intergenic | 1.2 [1.14-1.25] | 8x10-15 | [28] Scott LJ, Science 2007 | ||||
| rs2383208-A | Intergenic | 1.34 [1.27-1.41] | 2x10-29 | [30] Takeuchi F, Diabetes 2009 | ||||
| rs7018475-? | intergenic | 1.35 [1.18-1.56] | 3x10-8 | [45] Huang J, Eur J Hum Genet 2012 | ||||
| 13 | 2008 | JAZF1 | 7p15.1 | rs864745-T | Intron | 1.1 [1.07-1.13] | 5x10-14 | [31] Zeggini E, Nat Genet 2008 |
| 14 | CDC123 - CAMK1D | 10p13 | rs12779790-G | Intergenic | 1.11 [1.07-1.14] | 1x10-10 | [31] Zeggini E, Nat Genet 2008 | |
| 15 | TSPAN8 - LGR5 | 12q21.1 | rs7961581-C | Intergenic | 1.09 [1.06-1.12] | 1x10-9 | [31] Zeggini E, Nat Genet 2008 | |
| 16 | THADA | 2p21 | rs7578597-T | Mssense | 1.15 [1.10-1.20] | 1x10-9 | [31] Zeggini E, Nat Genet 2008 | |
| 17 | ADAMTS9 - MAGI1 | 3p14.1 | rs4607103-C | Intergenic | 1.09 [1.06-1.12] | 1x10-8 | [31] Zeggini E, Nat Genet 2008 | |
| 18 | NOTCH2 | 1p12 | rs10923931-T | Intron | 1.13 [1.08-1.17] | 4x10-8 | [31] Zeggini E, Nat Genet 2008 | |
| 19 | KCNQ1 | 11p15.4 | rs2237892-C | Intron | 1.4 [1.34-1.47] | 2x10-42 | [33] Yasuda K, Nat Genet 2008 | |
| rs2237897-C | intron | 1.33 [1.24-1.41] | 1x10-16 | [27] Unoki H, Nat Genet 2008 | ||||
| rs231362-G | Intron | 1.08 [1.06-1.10] | 3x10-13 | [34] Voight BF, Nat Genet 2010 | ||||
| rs2237895-C | Intron | 1.29 [1.19-1.40] | 1x10-9 | [38] Tsai FJ, PLoS Genet 2010 | ||||
| 20 | 2009 | LOC64673, IRS1 | 2q36.3 | rs2943641-C | Intergenic | 1.19 [1.13-1.25] | 9x10-12 | [35] Rung J, Nat Genet 2009 |
| 21 | 2010 | RBMS1, ITGB6 | 2q24.2 | rs7593730-C | Intron | 1.11 [1.08-1.16] | 4x10-8 | [36] Qi L, Hum Mol Genet 2010 |
| 22 | CENTD2 | 11q13.4 | rs1552224-A | intron | 1.14 [1.11-1.17] | 1x10-22 | [34] Voight BF, Nat Genet 2010 | |
| 23 | KIAA1486 - IRS1(IRS1) | 2q36.3 | rs7578326-A | intergenic | 1.11 [1.08-1.13] | 5x10-20 | [34] Voight BF, Nat Genet 2010 | |
| 24 | BCL11A | 2p16.1 | rs243021-A | intergenic | 1.08 [1.06-1.10] | 3x10-15 | [34] Voight BF, Nat Genet 2010 | |
| 25 | MTNR1B | 11q14.3 | rs1387153-T | intergenic | 1.09 [1.06-1.11] | 8x10-15 | [34] Voight BF, Nat Genet 2010 | |
| 26 | ZBED3 | 5q13.3 | rs4457053-G | intergenic | 1.08 [1.06-1.11] | 3x10-12 | [34] Voight BF, Nat Genet 2010 | |
| 27 | PRC1 | 15q26.1 | rs8042680-A | intron | 1.07 [1.05-1.09] | 2x10-10 | [34] Voight BF, Nat Genet 2010 | |
| 28 | KLF14 | 7q32.3 | rs972283-G | intergenic | 1.07 [1.05-1.10] | 2x10-10 | [34] Voight BF, Nat Genet 2010 | |
| 29 | DUSP9 | Xq28 | rs5945326-A | intergenic | 1.27 [1.18-1.37] | 3x10-10 | [34] Voight BF, Nat Genet 2010 | |
| 30 | TP53INP1 | 8q22.1 | rs896854-T | intron | 1.06 [1.04-1.09] | 1x10-9 | [34] Voight BF, Nat Genet 2010 | |
| 31 | ZFAND6 | 15q25.1 | rs11634397-G | intergenic | 1.06 [1.04-1.08] | 2x10-9 | [34] Voight BF, Nat Genet 2010 | |
| 32 | HMGA2 | 12q14.3 | rs1531343-C | UTR-3 | 1.1 [1.07-1.14] | 4x10-9 | [34] Voight BF, Nat Genet 2010 | |
| 33 | HNF1A | 12q24.31 | rs7957197-T | intron | 1.07 [1.05-1.10] | 2x10-8 | [34] Voight BF, Nat Genet 2010 | |
| 34 | C2CD4A,C2CD4B | 15q22.2 | rs7172432-A | intergenic | 1.11 [1.08-1.14] | 9x10-14 | [37] Yamauchi T, Nat Genet 2010 | |
| 35 | PTPRD | 9p24.1 | rs17584499-T | intron | 1.57 [1.36-1.82] | 9x10-10 | [38] Tsai FJ, PLoS Genet 2010 | |
| 36 | SRR | 17p13.3 | rs391300-G | intron | 1.28 [1.18-1.39] | 3x10-9 | [38] Tsai FJ, PLoS Genet 2010 | |
| 37 | CDC123,CAMK1D | 10p13 | rs10906115-A | intergenic | 1.13 [1.08-1.18] | 1x10-8 | [39] Shu XO, PLoS Genet 2010 | |
| 38 | SPRY2 | 13q31.1 | rs1359790-G | intergenic | 1.15 [1.10-1.20] | 6x10-9 | [39] Shu XO, PLoS Genet 2010 | |
| 39 | 2011 | C6orf57 | 6q13 | rs1048886-G | missense | 1.54 [1.32-1.80] | 3x10-8 | [40] Sim X, PLoS Genet. 2011 |
| 40 | AP3S2 | 15q26.1 | rs2028299-C | UTR-3 | 1.1 [1.07-1.13] | 2x10-11 | [41] Kooner JS, Nat Genet 2011 | |
| 41 | HMG20A | 15q24.3 | rs7178572-G | intron | 1.09 [1.06-1.12] | 7x10-11 | [41] Kooner JS, Nat Genet 2011 | |
| 42 | GRB14 | 2q24.3 | rs3923113-A | intergenic | 1.09 [1.06-1.13] | 1x10-8 | [41] Kooner JS, Nat Genet 2011 | |
| 43 | ST6GAL1 | 3q27.3 | rs16861329-G | intron | 1.09 [1.06-1.12] | 3x10-8 | [41] Kooner JS, Nat Genet 2011 | |
| 44 | VPS26A | 10q22.1 | rs1802295-A | UTR-3 | 1.08 [1.05-1.12] | 4x10-8 | [41] Kooner JS, Nat Genet 2011 | |
| 45 | MAEA | 4p16.3 | rs6815464-C | Intron | 1.13 [1.10-1.16] | 2x10-20 | [42] Cho YS, Nat Genet 2011 | |
| 46 | GLIS3 | 9p24.2 | rs7041847-A | Intron | 1.1 [1.07-1.13] | 2x10-14 | [42] Cho YS, Nat Genet 2011 | |
| 47 | FITM2,R3HDML,HNF4A | 20q13.12 | rs6017317-G | Intergenic | 1.09 [1.07-1.12] | 1x10-11 | [42] Cho YS, Nat Genet 2011 | |
| 48 | GCC1,PAX4 | 7q32.1 | rs6467136-G | intergenic | 1.11 [1.07-1.14] | 5x10-11 | [42] Cho YS, Nat Genet 2011 | |
| 49 | PSMD6 | 3p14.1 | rs831571-C | Intergenic | 1.09 [1.06-1.12] | 8x10-11 | [42] Cho YS, Nat Genet 2011 | |
| 50 | ZFAND3 | 6p21.2 | rs9470794-C | Intron | 1.12 [1.08-1.16] | 2x10-10 | [42] Cho YS, Nat Genet 2011 | |
| 51 | PEPD | 19q13.11 | rs3786897-A | Intron | 1.1 [1.07-1.14] | 1x10-8 | [42] Cho YS, Nat Genet 2011 | |
| 52 | KCNK16 | 6p21.2 | rs1535500-T | intron | 1.08 [1.05-1.11] | 2x10-8 | [42] Cho YS, Nat Genet 2011 | |
| 53 | 2012 | RBM43, RND3 | 2q23.3 | rs7560163-C | Intergenic | 1.33 [1.19-1.49] | 7x10-9 | [43] Palmer ND, PLoS One 2012 |
| 54 | ANK1 | 8p11.21 | rs515071-C | intron | 1.18 [1.12-1.25] | 1x10-8 | [44] Imamura M, Hum Mol Genet 2012 |