Table 1.
Physiological Measurements in Each Group After Middle Cerebral Artery Occlusion MCAO).
| Group | pH | PaCO2 (mm Hg) | PaO2 (mm Hg) | Glucose (mg / dl) | Mean arterial blood pressure (mmHg) | HCO3 (mM) | Body weight (g) |
|---|---|---|---|---|---|---|---|
| C ORT – M | 7.38 ± 0.02 | 38.1 ± 2.9 | 105.3 ± 7.8 | 128 ± 12 | 67 ± 4 | 26.6 ± 2.3 | 41.8 ± 5.0 |
| A ORT – M | 7.35 ± 0.05 | 38.3 ± 4.3 | 89.3 ± 7.8 | 130 ± 21 | 76 ± 8 | 25.2 ± 1.4 | 45.7 ± 6.0 |
| C ERT – M | 7.41 ± 0.03 | 39.9 ± 4.4 | 90.7 ± 14.2 | 131 ± 14 | 67 ± 7 | 25.2 ± 2.8 | 42.6 ± 5.2 |
| A ERT – M | 7.38 ± 0.03 | 41.0 ± 4.6 | 97.3 ± 5.8 | 130 ± 5 | 65 ± 3 | 26.1 ± 1.5 | 37.3 ± 3.5 |
| C ORT – F | 7.40 ± 0.04 | 39.1 ± 4.3 | 91.3 ± 19.8 | 126 ± 8 | 79 ± 3 | 24.5 ± 1.1 | 31.8 ± 4.1 |
| A ORT – F | 7.38 ± 0.01 | 39.8 ± 3.8 | 81.7 ± 7.6 | 110 ± 20 | 69 ± 5 | 26.1 ± 3.2 | 32.7 ± 1.5 |
| C ERT – F | 7.38 ± 0.03 | 40.0 ± 3.7 | 92.7 ± 6.9 | 105 ± 16 | 71 ± 6 | 26.8 ± 2.5 | 33.6 ± 4.7 |
| A ERT – F | 7.38 ± 0.06 | 37.4 ± 2.8 | 92.7 ± 4.2 | 115 ± 17 | 65 ± 6 | 25.0 ± 2.3 | 33.3 ± 2.7 |
No differences were seen in physiological variables between oil- and E2-treated mice of either sex prior to (not shown) and 60 min after MCAO, except body weight (*P < 0.05 versus male counterpart) (n= 4 per group, except body weight group, where n= 6 per group). C, chronic; A, acute; M, male; F, female; ORT, oil pellets replacement therapy; ERT, oestrogen replacement therapy.