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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Dec 20;23(5):1511–1518. doi: 10.1016/j.bmcl.2012.12.015

Table 1.

Activity of Potential Bifunctional Inhibitors in HIV-infected Cell Culture

Compound EC50 IC50
d4T 2.2 μM > 100 μM
8-Cl-TIBO 14 nM > 100 nM
d4T-4PEG-TIBO (16a) 45 μM > 100 μM
d4T-5PEG-TIBO (16b) 100 μM > 100 μM
d4T-6PEG-TIBO (16c) 120 μM > 100 μM
N3-d4U-6PEG-TIBO (22) 20 μM 38 μM
TIBO-6PEG (2c) 27 μM > 100 μM

Compounds were tested for their in vitro effect on viral replication. EC50 – antiviral potency; IC50 – cellular toxicity.