Table 1.
Evidence of association to schizophrenia from candidate gene studies for selected DISC1 interactors. Evidence for association was identified using SZGene (http://www.szgene.org/, updated 23 December 2011). The table shows those found in SZGene, the total number of studies (both case-control and familial) listed in SZGene, and whether any SNP remained significant after meta-analysis. Note: Only those SNPs with published genotype data in at least four independent case-control samples eligible for analysis were subjected to meta-analysis by SZGene (see http://www.szgene.org/methods.asp for details).
| gene | present in SZgene |
number of studies |
results | meta-analysis significant SNPs |
|---|---|---|---|---|
| DISC1 | Y | 45 studies | 31 positive/9 negative/ 3 trend |
rs3737597, rs999710 |
| AKT1 | Y | 17 studies | 9 positive/7 negative/1 trend | rs3803300 |
| ATF4 | Y | 1 study | negative | |
| ATF5 | Y | 1 study | negative | |
| BBS1 | ||||
| BBS4 | ||||
| CCDC141 | ||||
| CCDC88A (encodes KIAA 1212/Girdin) |
||||
| CIT | Y | 1 study | positive | |
| DIXDC1 | ||||
| FEZ1 | Y | 5 studies | negative | |
| GRB2 | ||||
| GSK3β | Y | 8 studies | 1 positive/6 negative/1 trend | |
| KALRN (encodes KAL-7) |
||||
| NDE1 | Y | 4 studies | negative | |
| NDEL1 | Y | 7 studies | 4 positive/3 negative | |
| PAFAH1B1 (encodes LIS1) |
Y | 5 studies | 1 positive/4 negative | |
| PCM1 | Y | 7 studies | 6 positive/1 negative | |
| PCNT | Y | 3 studies | 1 positive/1 negative/1 trend | |
| PDE4A | ||||
| PDE4B | Y | 12 studies | 9 positive/3 negative | rs910694 |
| PDE4C | ||||
| PDE4D | Y | 2 studies | positive | |
| SLC12A2 (encodes NKCC1) |
||||
| TNIK | ||||
| YWHAE (encodes 14-3-3s) |
Y | 5 studies | 2 positive/3 negative |