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. 2013 Feb;104(2):115–126. doi: 10.1111/j.1423-0410.2012.01648.x

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© 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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(a) Quantification of anti-A (black box) and anti-B (white box) haemagglutinins in five liquid intravenous immunoglobulin (IVIg) products tested in triplicates at 0·23–30 g/l using flow cytometry assay. Data represent the fluorescence intensity ratio [mean ± standard deviation (SD)] between each sample line slope and positive control from EDQM (Y0001152). (b) Specific lysis of red blood cells from A, B, AB and O Rh(D) negative groups induced by five liquid IVIg products (ClairYg® (▪), Octagam® (), Kiovig® (○), Gamunex® (◊), Privigen® () or [positive control ()] in the presence of guinea-pig complement.

Inline graphic — (a) Quantification of anti-A (black box) and anti-B (white box) haemagglutinins in five liquid intravenous immunoglobulin (IVIg) products tested in triplicates at 0·23–30 g/l using flow cytometry assay. Data represent the fluorescence intensity ratio [mean ± standard deviation (SD)] between each sample line slope and positive control from EDQM (Y0001152). (b) Specific lysis of red blood cells from A, B, AB and O Rh(D) negative groups induced by five liquid IVIg products (ClairYg® (▪), Octagam® (), Kiovig® (○), Gamunex® (◊), Privigen® () or [positive control ()] in the presence of guinea-pig complement.