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. 2013 Feb;104(2):115–126. doi: 10.1111/j.1423-0410.2012.01648.x

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© 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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(a) Evaluation of classic complement activation pathway by C1q-binding intravenous immunoglobulin (IVIg) products. Wells were coated with human C1q and incubated with five IVIg preparations (three batches each) at eight concentration points. C1q binding was assessed using an anti-human IgG antibody (γ-chain specific). Results are expressed as the mean and SD of IVIg relative binding to C1q. (b) Evaluation of whole complement activation. After incubation of IVIg in diluted human serum at 37°C, the C5a release was assayed by enzyme-linked immunosorbent assay. Results represent the percentage of C5a release related to a maximal release obtained with LPS and are expressed as mean and SD on three batches of each IVIg.