Table 1.
Fractionation processes used for the five liquid intravenous immunoglobulin preparations tested
| Product | Plasma fractionation | Ion exchange step | Viral inactivation | Protein concentration, g/l | Formulation |
|---|---|---|---|---|---|
| Clayrig® | Ethanol/caprylate | Yes | SD + nanofiltration | 50 | Liquid pH 4·8 |
| Octagam® | Ethanol | No | SD + acidic pH | 50 | Liquid acidic pH |
| Kiovig® | Ethanol | Yes | SD + nanofiltration + acidic pH | 100 | Liquid acidic pH |
| Privigen® | Ethanol/caprylate | Yes | SD + nanofiltration + acidic pH | 100 | Liquid acidic pH |
| Gamunex® | Ethanol/caprylate | Yes | Caprylate + acidic pH | 100 | Liquid acidic pH |
SD, solvent/detergent.