Table 2. Meta-analysis of the association of Val62Ile polymorphism with AMD.
| Polymorphism | study | No. of studies | sample size (No.) |
Test of association |
Heterogeneity |
||||
|---|---|---|---|---|---|---|---|---|---|
| case | control | OR (95%CI) | Z | P value | Model | I2% | |||
| GG+GA avs AA |
Overall |
14 |
4438 |
6099 |
2.28 (1.48–3.52) |
3.74 |
0.0002 |
bR |
88 |
| Asian |
10 |
2771 |
3043 |
2.28 (1.75–2.97) |
6.13 |
<0.00001 |
R |
46 |
|
| Caucasian |
4 |
1667 |
3056 |
2.58 (0.84–7.91) |
1.66 |
0.1 |
R |
91 |
|
| GA versus AA |
Overall |
14 |
1917 |
4485 |
1.58 (1.13–2.19) |
2.71 |
0.007 |
R |
75 |
| Asian |
10 |
1259 |
1983 |
1.64 (1.30–2.08) |
4.13 |
<0.00001 |
cF |
27 |
|
| Caucasian |
4 |
658 |
2502 |
1.56 (0.70–3.45) |
1.09 |
0.28 |
R |
79 |
|
| GG versus AA |
Overall |
14 |
3003 |
3530 |
2.90 (1.95–4.30) |
5.28 |
<0.00001 |
R |
78 |
| Asian |
10 |
1720 |
1578 |
3.18 (2.37–4.28) |
7.66 |
<0.00001 |
R |
52 |
|
| Caucasian |
4 |
1283 |
1952 |
2.83 (0.76–10.62) |
1.54 |
0.12 |
R |
90 |
|
| G versus A |
Overall |
14 |
8876 |
12,198 |
1.77 (1.43–2.21) |
5.13 |
<0.00001 |
R |
89 |
| Asian |
10 |
5542 |
6086 |
1.85 (1.63–2.09) |
9.77 |
<0.00001 |
R |
46 |
|
| Caucasian | 4 | 3334 | 6112 | 1.73 (0.91–3.30) | 1.66 | 0.1 | R | 95 | |
avs: versus; bR=random-effect model; cF=fixed-effect model.