Table 2. MMP-1 and MMP-7 SNP genotype frequencies in POAG and PACG patients and unaffected controls.
|
Controls
n=118 (%) |
POAG
n=112 (%) |
p (χ2) |
p (χ2) |
OR (95% CI) |
PACG
n=82 (%) |
p (χ2) |
p (χ2) |
OR (95% CI) |
|
|---|---|---|---|---|---|---|---|---|---|
| MMP-1= c.-1607-1606insGG | |||||||||
|
1G/1G |
53(44.9) |
27(24) |
0.001 (13.04) | Reference |
25(30.5) |
0.09 (4.75) | Reference |
||
|
1G/2G |
45(38.1) |
49(44) |
0.01 (5.93) |
2.14 (1.10-4.15) |
36(43.9) |
0.10 (2.58) |
1.70 (0.85-3.41) |
||
| 2G/2G | 20(17.0) | 36(32) | <0.001 (12.35) | 3.53 (1.63-7.73) | 21(25.6) | 0.04 (4.16) | 2.23 (0.96-5.21) | ||
| MMP-7 = c.-181T>C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
TT |
43(36.4) |
36(32.1) |
0.35 (2.07) | Reference |
24(29.3) |
0.55 (1.18) | Reference |
||
|
TC |
57(48.3) |
64(57.1) |
0.31 (1.03) |
1.34 (0.73-2.47) |
43(52.4) |
0.35 (0.86) |
1.35 (0.68-2.69) |
||
| CC | 18(15.3) | 12(10.8) | 0.60 (0.27) | 0.80 (0.31-2.03) | 15(18.3) | 0.35 (0.86) | 1.49 (0.59-3.80) | ||