Table 4. MMP-9 SNP genotype frequencies in POAG and PACG patients and unaffected controls.
|
Controls
n=118 (%) |
POAG
n=112 (%) |
p (χ2) |
p (χ2) |
OR (95% CI) |
PACG
n=82 (%) |
p (χ2) |
p (χ2) |
OR (95% CI) |
|
|---|---|---|---|---|---|---|---|---|---|
| MMP-9 = c.-1562C>T | |||||||||
|
CC |
74(62.7) |
70 (62.5) |
0.24 (2.85) | Reference |
56(68.3) |
0.23 (2.93) | Reference |
||
|
CT |
37(31.3) |
40(35.7) |
0.22 (0.63) |
1.14 (0.63-2.06) |
25(30.5) |
0.71 (0.13) |
0.89 (0.46-1.73) |
||
| TT | 7(6) | 2(1.8) | 0.12 (2.37) | 0.30 (0.04-1.67) | 1(1.2) | 0.08 (2.91) | 0.19 (0.01-0.60) | ||
| MMP-9 = c.836A>G | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
AA |
40 (33.9) |
26(23.2) |
0.05 (5.75) | Reference |
15(18.3) |
<0.001 (12.13) | Reference |
||
|
AG |
53(44.9) |
48(42.9) |
0.30 (1.07) |
1.39 (0.71-2.75) |
32(39.0) |
0.20 (1.61) |
1.61 (0.72-3.60) |
||
| GG | 25(21.2) | 38(33.9) | 0.01 (5.64) | 2.34 (1.09-5.05) | 35(42.7) | <0.001 (11.27) | 3.73 (1.59-8.86) | ||