Table II.

Values of CLogP, Log P and Measured Human Permeability for Metoprolol and the 11 Drugs Where Predicted Permeabilities or Extent of Metabolism Did Not Match Measured Permeability Relative to Metoprolol. (Values from Ref. 16)

Drug	CLogP	Predicted Permeability	Log P	Predicted Permeability	Measured Human Permeability (×104cm/sec)	Permeability	Metabolism
antipyrine	0.20	L	1.01	L	5.60	H	H
cephalexin	−1.84	L	−0.67	L	1.56	H	L
D-glucose	−2.21	L	−2.38	L	10.00	H	H
enalapril	0.67	L	1.77	H	1.57	H	H
furosemide	1.90	H	0.74	L	0.05	L	L
levodopa	−2.82	L	0.00	L	3.40	H	H
L-leucine	−1.67	L	0.34	L	6.20	H	H
losartan	4.11	H	na		1.15	L	H
metoprolol	1.49	H	1.72	H	1.34	H	H
phenylalanine	−1.56	L	0.78	L	4.08	H	H
piroxicam	1.89	H	0.29	L	6.65	H	H
valacyclovir	−1.22	L	−1.06	L	1.66	H	H

na = not available