Table III.
The 20 Model Drugs Suggested by the FDA for Use in Establishing Suitability of a Permeability Method Together with Predictability Using CLogf P and Log P vs Predictability Using Extent of Metabolism
| Drug | Permeability Class | Predicted by CLogP and Log P | Predicted by Extent of Metabolisma |
|---|---|---|---|
| Antipyrine | High (Potential IS candidate) | No | Yes |
| Caffeine | High | No | Yes |
| Carbamazepine | High | Yes | Yes |
| Fluvastatin | High | Yes | Yes |
| Ketoprofen | High | Yes | Yes |
| Metoprolol | High (Potential IS candidate) | Yes | Yes |
| Naproxen | High | Yes | Yes |
| Propranolol | High | Yes | Yes |
| Theophylline | High | No | Yes |
| Verapamil | High (Potential ES Candidate) | Yes | Yes |
| Amoxicillin | Low | Yes | Yes |
| Atenolol | Low | Yes | Yes |
| Furosemide | Low | No | Yes |
| Hydrochlorthiazide | Low | Yes | Yes |
| Mannitol | Low (Potential IS candidate) | Yes | Yes |
| α-Methyldopa | Low | Yes | Yes |
| Polyethylene glycol (400) | Low | Yes | Yes |
| Polyethylene glycol (1000) | Low | Yes | Yes |
| Polyethylene glycol (4000) | Low (zero permeability marker) | Yes | Yes |
| Ranitidine | Low | Yes | Yes |
a
Using 70% as the cutoff